LABORATORIO DE ANÁLISIS DR.ECHEVARNE LABORATORIO DE ANÁLISIS DR.ECHEVARNE
LABORATORIO DE ANÁLISIS DR. ECHEVARNE
Clinical Trial Studies - Pharmacogenetics unit

LABORATORIO DE ANÁLISLaboratorio de análisis Dr. Echevarne - Estudios Clínicos

In therapeutic action against a disease, the first thing observed by a doctor is the inter-individual variability of the response, which is intrinsically linked to the genetic characteristics of the subject, modulated by physiological, pathological and environmental factors.
 Pharmaco-genetics is the science that makes it possible to identify the genetic basis of inter-individual differences in response to drugs. Along these lines, the development of pharmaco-genetics at least provide a way of making medical prescriptions without the current empiricism and to move towards more personalised therapy. At the Pharmaco-genetics Unit of the Dr. Echevarne analysis laboratory, we have the right techniques and methods to help doctors with this work.

ANALYTICAL TECHNIQUES
• Gene amplification by PCR: qualitative and quantitative
• RFLP (Restriction Fragment Length Polymorphism)
• SSCP (Single Strand Conformational Polymorphism)
• DNA sequencing
• Cell cultures
• Nucleic acid hybridisation:

  - Northern blot (RNA)
- Southern blot (DNA)

FIELDS OF ACTION

• Cytochrome p450 complex:
  - CYP2D6
- CYP2C19
- CYP3A5
• Acetylation
  - NAT2
• Anti-dementia drugs
  - APOE
• Anti-hypertension drugs
  - ACE
• Replacement oestrogen therapy
  - COMT
• Hyperhomocystinemia treatment
  - MTFHR
- CBS
- MS
• SNPs at Beta-Adrenergic receptor level
  - Arg16Gly: Response to anti-asthma treatment
- Gln27Glu: Obesity
• Tirosine-kinase inhibitors:    
  - bcr/abl: Response to Imatinib
LABORATORIO DE ANÁLISIS DR. ECHEVARNE
  Phase I Clinical Trials
Phase II-IV Clinical Trials
Bioanalysis-Pharmacokinetic
Pharmacogenetics
LABORATORIO DE ANALAISIS DR. ECEHEVARNE
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