Análisis Clínicos - Unidad de Toxicología
| Biomarkers
of work exposition |
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The main area of action of the Toxicology Unit is the analysis of biomarkers for workplace exposure to chemical substances, basically metals and solvents. To evaluate the results obtained, the INSHT biological limit values are used, together with those from other international bodies with recognised prestige (ACGIH, SUVA, FIOH, HSE-HSL, DFG, etc.).
Another area of action is the Therapeutic Drug Monitoring (TDM) so that the clinician can adjust and/or evaluate the treatment the patient is undergoing. This includes therapeutic groups like anti-epilepsy drugs, digoxin, theophylline, immuno-suppressants, antibiotics, benzodiazepines, etc.
Confirmation is also carried out using Gas Chromatography-Mass Spectrometry (GC-MS) of analyses when required because positives for abused drugs have been given in urine in the initial screening analysis. To evaluate the results obtained, international criteria are used (Federal Register / USA or EWDTS, etc.).
All this has made it an instrumental unit now covering other fields of activity, such as anti-aging biomarkers and others related to the area of food (metals, vitamins, fatty acids W3-W6, breath test, etc.).
ANALYTICAL TECHNIQUES
• Gas chromatography: |
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- Flame Ionisation Detector (FID)
- Electron Capture Detector (ECD)
- Mass Spectrometry (MS)
- Head Space |
| • Liquid Chromatography (HPLC): |
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- Ultraviolet
- Fluorescence |
| • Infra-red Spectroscopy |
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- FT-IR System |
• Molecular absorption photo-spectrometry (UV-VIS)
• Atomic Absorption Photo-spectrometry (AAS): |
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- Flame
- Graphite Zeeman Chamber |
• Spectrofluorimetry
• Oxymetry
• ISE
• Volumetries
• Induced coupled plasma mass espectometry (ICP-MS)
FIELDS OF ACTION
• Confirmation of abused drugs by gas chromatography-mass
 spectrometry (GC-MS)
• Analysis and biological tests for substances (metals, solvents,
etc.) involved in exposure at work
• Analysis of clinical samples by gas chromatography and gas
chromatography-mass spectrometry (GC-MS)
• Analysis of clinical samples by liquid chromatography (HPLC)
• Analysis of clinical samples by atomic absorption (AA) and ICP-MS |
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