Departments    Clinical Trial Studies    Pharmacogenetics unit     Director:   Dr. José Ignacio Lao      ANALYTICAL TECHNIQUES - - DNA and RNA amplificaton by PCR: qualitative and quantitative - RFLP (Restriction Fragment Length Polymorphism) - SSCP (Single Stranded Conformation Polymorphism) - DNA sequencing - Cell cultures - Hybridisation of nucleic acids:       - Northern blot (RNA)       - Southern blot (DNA) WORKING AREAS - - Cytochromo P450 complex:     . CYP2D6     . CYP2C19     . CYP3A5 - Acetylation:     . NAT2 - Antidementia drugs:     . APOE - Antihypertensive drugs:     . ACE - Estrogen replacement therapy    . COMT - Hyperhomocysteinemia treatment:     . MTFHR     . CBS     . MS - Beta-Adrenergic receptor Snps:     . Arg16Gly: antiasmatic treatment answer     . Gln27Glu: Obesity - Specific inhibitors of Tyrosine Kinases:     . bcr/abl: Respuesta al Imatinib Phase I Clinical Trials Phase II-IV Clinical     Trials Bioanalysis-     Pharmacokinetic Pharmacogenetics