Departments    Industrial Analysis    Biological Toxicity Assaigs - Director:   Dr. Nuria Álvarez      This unit consists of a laboratory for in vitro assays and an animal house for the performance of different Good Laboratory Practise “GLP” techniques for in vivo testing. METHODS - - In vivo Tests - In vitro Tests   WORKING AREAS Cosmetic Industry - - Dermocosmetic evaluation. Human voluntary assays:      - Safety assays      - Efficacy assays - In vitroassays:      - Skin irritation in vitro method SKINTEX      - Eye irritation in vitro method EYTEX      - Hemolysis denaturation (RBC) (eye irritation) - In vivo assays:      - Skin irritation assays      - Eye irritation assays      - Reiterative skin irritation assays      - Cutaneous sensitivity Test (allergy)      - Comedogenesis Test      - Mucose irritation Test      - Photo-toxicity Test      - Photo-allergy Test Pharmaceutical Industry - In vivo assays: -      - Pyrogen assay      - Acute toxicity (LD50)      - Abnormal Toxicity (Safety Test)      - Local tolerance assay      - Mucose irritation assay(oral, rectal,vaginal,..)      - Antibody Collection      - Biological activity Tests hormones - In vitro assays:      - Bacterial Endotoxins (LAL) Health Products – Medical Accessories. Cutaneous pigments - - Biocompatibility assays according to ISO 10 9993 - In vivo assays:      - Intra-skin Test      - Systemic injection Test      - Skin sensibilisation Test      - Skin irritation Test      - Mucose irritation assays (oral, rectal,vaginal...)      - Acute toxicity (LD50) oral and/o skin      - Pyrogen assay      - Implantation Test - In vitro assays:      - Endotoxin assay Ind. Microbiology Analytical Chemistry Nutrition Biological Toxicity     Assaigs Image Analysis Environment Chemical Industry (REACH). Biocides. (Toxicological data for security files) - - Health safety evaluation assays      - Skin irritation assays      - Eye irritation assays      - Corrosion degree classification (according to chemical        storage recommendations)      - Skin sensibilisation assays      - Acute toxicity assay (LD50) oral      - Acute toxicity assay (LD50) skin      - Inhaled acute toxicity      - Short term toxicity (repeated dose 28 days)      - Subchronic Toxicity 90 days*      - Ames test mutagenesis assays      - Reproductive toxicity assays*      - Toxico-kinetic assays - Eco-toxicity assays      - Acute toxicity in fish      - Acute toxicity in algae      - Acute toxicity in Daphnia      - Biotic degradation assays. Biodegradation assays.      - Long term toxicity in Daphnia - Long term toxicity in fish Miscellaneous - Botulin toxin detection in non-biological samples - Biological toxicity in waters and industrial residues:      - Microtox method (inhibitory materials)